1)Drug consult- PICO Questions In a 55-year old male with infective endocarditis (IE) caused by Enterococcus faecalis, is Ampicillin + Ceftriaxone
1) Drug consult- PICO QuestionsIn a 55-year old male with infective endocarditis (IE) caused by Enterococcus faecalis, is Ampicillin + Ceftriaxone (AC) as safe, efficacious and/or with fewer side effects as compared to Ampicillin + Gentamicin (AG)? Write background, recommendations and use references below to AMA cite,i) Backgroundii) Recommendationiii) AMA CitationsReferences to use belowRafei AE, Desimone DC, Narichania AD., et al. Comparison of Dual β-Lactam therapy to penicillin-aminoglycoside combination in treatment of Enterococcus faecalis infective endocarditis. J Infection. 2018;77(5):398-404. Fernández-Hidalgo N, Almirante B, Gavaldà J., et al. Ampicillin Plus Ceftriaxone Is as Effective as Ampicillin Plus Gentamicin for Treating Enterococcus faecalis Infective Endocarditis. Clin Infect Dis. 2013;56(9):1261-1268. Clinical Pharmacology Web site. https://www.clinicalpharmacology-ip.com/Forms/Monograph/monograph.aspx?cpnum=275&sec=monadve&t=0. Accessed January 25, 2019. Dynamed Website
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